• NTT Bio-Medical Informatics Research Center

    NTT Bio-Medical Informatics Research Center

    Aiming for data-driven medical and health support using ICT and AI, BMC promotes basic and applied R&D such as advanced analysis of medical and health data and behavior information, development of bio-monitoring devices, biocompatible new materials. We also promote the realization of Bio Digital Twin and co-innovation with external medical partners.

    About Us

    Project Manager Dr. Hiroshi Nakashima
    Project Manager
    Dr. Hiroshi Nakashima

    NTT Bio-Medical Informatics Research Center (BMC) has a mission to create data-driven medicine using ICT, and was established on July 1, 2019 as a new research organization in which five NTT research laboratories cooperated. BMC promotes basic and applied research such as biocompatible new materials, biosensing technology, medical care and behavioral information analysis technology, and co-innovation with partners. In addition, BMC cooperates with NTT Research Inc., Medical & Health Informatics Laboratories, which is overseas research and development bases, NTT operating companies such as NTT Life Science and the hospitals owned by NTT Group.

    Molecular and Bio Science Research Group

    Theme/Field

    Membrane proteins such as nuclear and biological molecules of the body-friendly, brain and interface with potential new device concepts Nanobio-device advocated the realization of the research assignments.

    Topics

    Dr. Masumi Yamaguchi
    Group Leader
    Dr. Masumi Yamaguchi

    Our research group's goal is to produce materials and bionanotechnology-oriented devices by using new concepts in biomolecule functionality and neuronal networks. We employ various techniques such as nano- and mircofabrication of fine structures, chemical synthesis and theoretical calculations. Particularly, we are interested in the dynamics and mechanics of lipidbilayers in microchannels and their applications, electrophysiology of neuronal circuits grown on microelectrode arrays, operation of metallic nano- structures and the assessment of its physical properties, and analysis of proteins on solid surfaces.

    Members

    Dr. Shingo Tsukada

    Dr. Shingo Tsukada

    Dr. Yoshiaki Kashimura

    Dr. Yoshiaki Kashimura

    Dr. Aya Tanaka

    Dr. Aya Tanaka

    Dr. Takayuki Ogasawara

    Dr. Takayuki Ogasawara

    Dr. Azusa Oshima

    Dr. Azusa Oshima

    Dr. Touichiro Goto

    Dr. Touichiro Goto

    Dr. Koji Sakai

    Dr. Koji Sakai

    Dr. Riku Takahashi

    Dr. Riku Takahashi

    Dr. Yosuke Mizuno

    Dr. Yosuke Mizuno

    Topics by Group

    Press Release

    Publications

    Publications in 2020

    1. S. Koyama, S. Tanabe, Y. Otaka, T. Kato, S. Furuzawa, T. Tatemoto, N. Kumazawa, H. Yoshimuta, K. Torii, S. Tsukada, and E. Saitoh

      Novel lateral transfer assist robot decreases the difficulty of transfer in post-stroke hemiparesis patients: a pilot study

      (Early Access Article) Disabil. Rehabil.-Assist. Technol. (2020).

    2. Y. Kashimura, K. Sumitomo, and H. Nakashima

      Biodevices using microwells sealed with artificial lipid bilayers: Improvement of sealing performance by protein coating

      Electr. Commun. Jpn. 103 (9) 15-22 (2020).

    3. A. Oshima, H. Nakashima, and K. Sumitomo

      Phase separation in freestanding bilayer lipid membrane induced by osmotic pressure difference

      Jpn. J. Appl. Phys. 59 (2), 027001 (2020).

    1. H. Matsuura, M. Mukaino, Y. Otaka, H. Kagaya, Y. Aoshima, T. Suzuki, A. Inukai, E. Hattori, T. Ogasawara, and E. Saitoh

      Validity of simplified, calibration-less exercise intensity measurement using resting heart rate during sleep: a method-comparison study with respiratory gas analysis

      BMC Sports Sci. Med. Rehabil. 11 (1), 27 (2019).

    2. T. Goto, N. Kasai, R. Filip, K. Sumitomo, and H. Nakashima

      Observation of intracellular protein localization area in a single neuron using gold nanoparticles with a scanning electron microscope

      Micron 126, UNSP 102740 (2019).

    3. R. Kou, Y. Kobayashi, S. Inoue, T. Tsuchizawa, Y. Ueno, S. Suzuki, H. Hibino, T. Yamamoto, H. Nakajima, and K. Yamada

      Dopamine detection on activated reaction field consisting of graphene-integrated silicon photonic cavity

      Opt. Express 27 (22) 32058-32068 (2019).

    4. A. Oshima, H. Nakashima, and K. Sumitomo

      Evaluation of Lateral Diffusion of Lipids in Continuous Membranes between Freestanding and Supported Areas by Fluorescence Recovery after Photobleaching

      Langmuir 35 (36) 11725-11734 (2019).

    5. R. Takahashi, H. Miyazako, A. Tanaka, and Y. Ueno

      Dynamic Creation of 3D Hydrogel Architectures via Selective Swelling Programmed by Interfacial Bonding

      ACS Appl. Mater. Interfaces 11 (31) 28267-28277 (2019).

    6. Y. Nakatani, K. Kawahara, K. Harada, A. Oshima, H. Nakashima, and K. Sumitomo

      Control of phase separation in freestanding lipid bilayer over microwells

      Jpn. J. Appl. Phys. 58, SIID06 (2019).

    7. K. Sakai, T. F. Teshima, H. Nakashima, and Y. Ueno

      Graphene-based neuron encapsulation with controlled axonal outgrowth

      Nanoscale 11 (28) 13249-13259 (2019).

    8. Y. Tsukada, M. Tokita, H. Murata, Y. Hirasawa, K. Yodogawa, Y. Iwasaki, K. Asai, W. Shimizu, N. Kasai, H. Nakashima, and S. Tsukada

      Validation of wearable textile electrodes for ECG monitoring

      Heart Vessels 34 (7) 1203-1211 (2019).

    9. Y. Ueno, K. Dendo, Y. Homma, and K. Furukawa

      Adhesive Layer for Robust Graphene Transferred on Solid Support and Its Application to Graphene Microelectrode Manufacturin

      Sens. Mater. 31 (4) 1157-1165 (2019).

    10. A. Oshima, and K. Sumitomo

      Vesicle Fusion with Artificial Bilayer Lipid Membrane Induced by Electrostatic Interaction

      Bunseki Kagaku 68 (1) 23-32 (2019).

    11. T. F. Teshima, C. S. Henderson, M. Takamura, Y. Ogawa, S. N. Wang, Y. Kashimura, S. Sasaki, T. Goto, H. Nakashima, and Y. Ueno

      Self-Folded Three-Dimensional Graphene with a Tunable Shape and Conductivity

      Nano Lett. 19 (1) 461-470 (2019).

    1. Y. Ueno, T. Teshima, C. S. Henderson, and H. Nakashima

      Fabrication of Graphene Microroll Aptasensor

      Sens. Mater. 30 (12) 2989-2998 (2018).

    2. Y.Ueno and K. Furukawa

      On-Chip FRET Graphene Aptasensor

      IJAT 12, 37-44 (2018).

    3. K. Ajito, Y. Ueno, J. Y. Kim, and T. Sumikama

      Capturing the Freeze-Drying Dynamics of NaCl Nanoparticles Using THz Spectroscopy

      J. Am. Chem. Soc. 140 (42) 13793-13797 (2018).

    4. W. Choi, H. Nishiyama, Y. Ogawa, Y. Ueno, K. Furukawa, T. Takeuchi, Y. Tsutsui, T. Sakurai, and S. Seki

      Relaxation of Plasma Carriers in Graphene: An Approach by Frequency-Dependent Optical Conductivity Measurement

      Adv. Opt. Mater. 6 (14), 1701402 (2018).

    5. A. Tanaka, Y. Fujii, N. Kasai, T. Okajima, and H. Nakashima

      Regulation of neuritogenesis in hippocampal neurons using stiffness of extracellular microenvironment

      PLoS One 13 (2), e0191928 (2018).

    1. T. F. Teshima, H. Nakashima, Y. Ueno, S. Sasaki, C. S. Henderson and S. Tsukada

      Cell Assembly in Self-foldable Multi-layered Soft Micro-rolls

      Sci Rep 7, 17376 (2017).

    2. A. Oshima and K. Sumitomo

      Vesicle fusion with bilayer lipid membrane controlled by electrostatic interaction

      Biochem Biophys Rep. 11 58-63 (2017)

    3. K. Sumitomo and A. Oshima

      Liquid-Ordered/Liquid-Crystalline Phase Separation at a Lipid Bilayer Suspended over Microwells

      Langmuir, 2017, 33 (46), pp 13277–13283

    4. K. Furukawa, T. Teshima, and Y. Ueno

      Self-propelled ion gel at air-water interface

      Sci Rep 7, 9323 (2017).

    5. R. Ohta, Y. Ueno, and K. Ajito

      Raman Spectroscopy of Pharmaceutical Cocrystals in Nanosized Pores of Mesoporous Silica

      Anal. Sci. 33 (1) 47-52 (2017).

    1. N. Kasai

      Nano-biointerfaces for Detection and Control of Biological Information

      Electrochemistry 84 (9), 688-694 (2016).

    2. K. Furukawa, Y. Ueno, M. Takamura and H. Hibino

      Graphene FRET Aptasensor

      ACS Sens. 1 (6), 710-716 (2016).

    3. N. Kasai, R. Lu, R. Filip, T. Goto, A. Tanaka and K. Sumitomo

      Neuronal Growth on a-Si and Au Nanopillars

      Electrochemistry 84 (5), 296-298 (2016).

    4. T. Goto, N. Kasai, R. Lu, R. Filip and K. Sumitomo

      Scanning Electron Microscopy Observation of Interface Between Single Neurons and Conductive Surfaces

      J. Nanosci. Nanotechnol. 16 (4), 3383-3387 (2016).

    5. M. Godonoga, T. Y. Lin, A. Oshima, K. Sumitomo, M. S. L. Tang, Y. W. Cheung, A. B. Kinghorn, R. M. Dirkzwager, C. S. Zhou, A. Kuzuya, J. A. Tanner and J. G. Heddle

      A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly

      Sci Rep. 6 21266 (2016).

    6. T. Teshima, H. Nakashima, N. Kasai, S. Sasaki, A. Tanaka, S. Tsukada, and K. Sumitomo

      Mobile Silk Fibroin Electrode for Manipulation and Electrical Stimulation of Adherent Cells

      Adv. Funct. Mater. 26 (45) 8185-8193 (2016).

    1. R. Forbes, Y. Kashimura and K. Sumitomo

      Hermetically sealed microwell with a lipid bilayer created using a self-assembled monolayer

      Appl. Phys. Express 8, 117201 (2015).

    2. A. Tanaka, H. Nakashima, Y. Kashimura and K. Sumitomo

      Electrostatically induced planar lipid membrane formation on a cationic hydrogel array by the fusion of small negatively charged unilamellar vesicles

      Colloid Surf. A-Physicochem. Eng. Asp. 477, 63-69 (2015).

    3. A. Tanaka, R. Tanaka, N. Kasai, S. Tsukada, T. Okajima and K. Sumitomo

      Time-lapse imaging of morphological changes in a single neuron during the early stages of apoptosis using scanning ion conductance microscopy

      J. Struct. Biol. 191, 32-38 (2015).

    4. H. Akazawa and Y. Ueno

      Control of surface wettability of hydroxyapatite thin films by way of crystal imperfections

      Appl. Phys. Express 8, 107001 (2015).

    5. Y. Ueno, K. Furukawa, A. Tin and H. Hibino

      On-chip FRET Graphene Oxide Aptasensor: Quantitative Evaluation of Enhanced Sensitivity by Aptamer with a Double-stranded DNA Spacer

      Anal. Sci. 31, 875-879 (2015).

    1. T. Goto, Y. Harada, D. Cox and K. Sumitomo

      Fabrication of a ring structure at the aperture of a hole for the efficient suspension of a lipid bilayer

      Jpn. J. Appl. Phys. 53 (9), 096503 (2014).

    2. Y. Kashimura, K. Sumitomo and K. Furukawa

      Electrostatic control of the dynamics of lipid bilayer self-spreading using a nanogap gate

      Mater. Res. Express 1 (3), 035404 (2014).

    3. Y. Shinozaki, A. Tanaka, N. Kasai, K. Torimitsu and K. Sumitomo

      Ligand-induced structural changes in a membrane-reconstituted ion channel observed with atomic force microscopy

      Appl. Phys. Express 7 (2), 027001 (2014).

    4. A. Tanaka, Y. Kashimura, E. Kuramochi and K. Sumitomo

      Formation of a suspended lipid membrane on a microcavity covered by a thin SiO2 layer with a nanohole array

      Appl. Phys. Express 7 (1), 017001 (2014).

    5. A. Tanaka, H. Nakashima, Y. Kashimura and K. Sumitomo

      Fabrication of a gel-supported lipid membrane array on a silicon substrate

      Jpn. J. Appl. Phys. 53 (1), 01AF02 (2014).

    6. N. Kasai, R. Lu, T. Goto, A. Tanaka, S. Tsukada, Y. Harada and K. Sumitomo

      Observation of Neuronal Death In Vitro by SEM and Optical Microscopy

      e-Journal of Surface Science and Nanotechnology 12, 179-184 (2014)..

    1. J. Baranovic, CS. Ramanujan, N. Kasai, CR. Midgett, DR. Madden, K. Torimitsu, and JF. Ryan

      Reconstitution of Homomeric GluA2flop Receptors in Supported Lipid Membranes FUNCTIONAL AND STRUCTURAL PROPERTIES

      J. Biol. Chem. 288 (12), 8647-8657 (2013).

    2. J. Brown, P. Kocher, CS. Ramanujan, DN. Sharp, K. Torimitsu, and JF. Ryan

      Electrically conducting, ultra-sharp, high aspect-ratio probes for AFM fabricated by electron-beam-induced deposition of platinum

      Ultramicroscopy 133, 62-66 (2013).

    3. Y. Furukawa, A. Shimada, K. Kato, H. Iwata, and K. Torimitsu

      Monitoring neural stem cell differentiation using PEDOT-PSS based MEA

      Biochim. Biophys. Acta-Gen. Subj. 1830 (9), 4329-4333 (2013).

    4. Y. Kashimura, K. Furukawa, and K. Torimitsu

      Electrostatic Control of Artificial Cell Membrane Spreading by Tuning the Thickness of an Electric Double Layer in a Nanogap

      IEICE Trans. Electron. E86C (3), 344-347 (2013).

    1. AD. Malay, JG. Heddle, S. Tomita, K. Iwasaki, N. Miyazaki, K. Sumitomo, H. Yanagi, I. Yamashita, and Y. Uraoka

      Gold Nanoparticle-Induced Formation of Artificial Protein Capsids

      Nano Letters 12 (4), 20562059 (2012).

    2. H. Nakashima, MJ. Higgins, C. O'Connell, K. Torimitsu, and GG. Wallace

      Liquid Deposition Patterning of Conducting Polymer Ink onto Hard and Soft Flexible Substrates via Dip-Pen Nano lithography

      Langmuir 28 (1), 804811 (2012).

    3. C. O'Connell, MJ. Higgins, H. Nakashima, SE. Moulton, and GG. Wallace

      Vapor Phase Polymerization of EDOT from Submicrometer Scale Oxidant Patterned by Dip-Pen Nanolithography

      Langmuir 28 (26), 99539960 (2012).

    4. K. Sumitomo, A. McAllister, Y. Tamba, Y. Kashimura, A. Tanaka, Y. Shinozaki, and K. Torimitsu

      Ca2+ ion transport through channels formed by alpha-hemolysin analyzed using a microwell array on a Si substrate

      Biosensors & Bioelectronics 31 (1), 445450 (2012).

    5. S. Tsukada, H. Nakashima, and K. Torimitsu

      Conductive Polymer Combined Silk Fiber Bundle for Bioelectrical Signal Recording

      Plos One 7 (4), e33689 (2012).